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Cancer Stem Cells

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Keytruda: Toxic, Expensive and Not So Effective

Best Selling Cancer Drug in 2019 Keytruda® (pembrolizumab) is toxic, expensive, and not as effective as one would wish. But at $7.2 billion, it was the best-selling cancer drug in 2019. At the...

Immunotherapy: The Battle Within - Film

Immunotherapy: The Battle Within – Film

Immunotherapy: The Battle Within (The Film) The Moss Report has produced an hour-long documentary, “Immunotherapy: The Battle Within.” which is free to watch below. Creating this film has been a...

Kombucha Benefits are Cloudy

A Fermented Drink I hadn’t thought about drinking kombucha tea until I saw a row of brightly colored glass bottles on a shelf in my local supermarket. For the uninitiated, kombucha is a fermented...

Is Chemotherapy Toxic?

Considering Toxicity Let us consider the question of toxicity, which we discussed in articles on specific trials of so-called “Precision Medicine’ for cancer. When targeted therapy was first...

Green Tea as an Immune Checkpoint Inhibitor

Value in Prevention and Treatment One of the most exciting developments in cancer in the past 30 years has been a treatment strategy known as immune checkpoint blockade. ICB relies on a...

Avastin for Breast Cancer

A Top Selling Cancer DrugIn 2008, the FDA approved Avastin (bevacizumab) as a treatment for advanced breast cancer. This approval was based on a small trial called E2100, which showed a...

Do “Targeted Therapies” Hit the Mark?

The Cancer Genome Landscape The journal Science published a revealing report on the work of Charles Swanton, MD, showing that “tumors are a mosaic of different cells” (Gerlinger 2012)....

Key Characteristics Of Cancer Cells

[Hippocrates, c. 460-370 BCE, the so-called father of Western medicine. Illustration of a bust in the Uffizi Gallery, Florence, illustration courtesy of Wikimedia Commons] Life is Short and Art...

Progress Against Chronic Lymphocytic Leukemia

Penn’s Therapy for CLL Relapsed chronic lymphocytic leukemia (CLL) is not the easiest disease to treat. That is why a small series of cases is attracting great attention. Using a...

Fecal Microbiota Transplantation

Altering Gut Microbiota This is a treatment that is hard to classify! Fecal microbiota transplantation (FMT) refers to the transfer of fecal matter from one individual to another. When used...

Harvard Professors Question Surgery

Do Operations Speed the Growth of Tumors? The conventional approach to breast cancer consists of mammography, followed by biopsy, and surgery, with or without adjuvant radiation. This has been...

Prof. Swanton Shakes Biologists

Revealing Report Science described a revealing report on the work of Charles Swanton, MD, of the Francis Crick Institute, of the U.K. showing that “tumors are a mosaic of different cells”...

Circulating Tumor Cells (CTCs)

Detected and Recovered From the Blood Stream Circulating tumor cells (CTCs) are cancer cells that can be detected and recovered from the bloodstream. They have detached from the primary tumor and...

Considering Clinical Trials

Toxicity vs Benefits In a Phase I clinical trial, scientists give a new drug in various doses to a small group of patients and then evaluate its effects on the body. Patients with many different...

Do PARP Inhibitors Work?

Poly ADP Ribose Polymerase The acronym PARP stands for “poly ADP ribose polymerase.” For the past few years, a great many hopes have been riding on the alleged effectiveness of this...

Patient-Initiated Testing

Testing for Circulating Tumor Cells Naturally, some patients want to proactively arrange for their own testing. Many want to know if they can make useful suggestions to their medical caregivers....

Circulating Tumor Cell (CTC) Testing

CellSearch® from Quest Diagnostics Circulating Tumor Cell (CTC) testing means quantifying the number of CTCs that can yield information regarding a patient’s prognosis and survival. In addition,...

CellSearch – Tests for Cancer

Noninvasive Blood Testing This is an exciting time for noninvasive blood tests for cancer. Several biotech companies are vying to become the first to introduce a “liquid biopsy.” This is a blood...

NCCN Recommendations for NSCLC

Setting the StandardThe National Comprehensive Cancer Network (nccn.org) is an alliance of 32 U.S. cancer centers. Their experts diagnose and treat all cancers, but with a focus on complex,...

Bone Sarcoma Research Resources

References to the Natural Treatment of SarcomasHere are some references to the natural treatment of sarcomas. Since sarcoma represents only about 1% of all cancers, the evidence for the...

Causes of Cancer

Transcript There's a lot of confusion over what causes cancer, and a lot of people have sort of dogmatic attitudes towards this that aren't really warranted by the evidence. The most confusing...

Chemo Resources & Side Effect Remedies

Transcript When you're doing research into chemotherapy, you definitely want to know what the side effects are of the different drugs, and there's actually a very, very good website that can get...

Curcumin & Turmeric

Transcript The words turmeric and curcumin come up very frequently in discussions about cancer, and they are certainly indispensable items. Turmeric is a rhizome or a root of a plant, and it's...

Immune System

Transcript Another huge topic in cancer is the state of the immune system. And I believe that this theory, the immune surveillance theory that was put forward by Mack Macfarlane in the 1950s is...

Avastin® and Ovarian Cancer – Any Benefit?

Top Cancer Drug Bevacizumab (Avastin®) is, economically speaking, the top cancer drug in the world. Sales in 2010 topped $6.9 billion. One of the reasons for this financial success has been its...

Cancer: Different Diagnoses, Same Disease?

The common biology behind different diagnosis One question we sometimes hear is “Why are we providing information on cancer types other than my own?” Some people are so singularly focused on...

An Honor Roll of Complementary Medicine

“If I have seen further, it is by standing on the shoulders of Giants.” —Sir Isaac Newton (1675) Pioneers in Science In a White House ceremony on December 23, 1971, Richard M. Nixon declared “War...