Immune Checkpoint Drug History
The Long History of Immune Checkpoint Inhibitors It does not diminish Jim Allison’s remarkable achievements to note that scientists have long known that tumors employ mechanisms to block the...
The Long History of Immune Checkpoint Inhibitors It does not diminish Jim Allison’s remarkable achievements to note that scientists have long known that tumors employ mechanisms to block the...
Combining Therapies “There was a traditional notion that combining immunotherapy and chemotherapy may not be desirable due to the possible immunosuppressive nature of cytotoxic chemotherapy....
How Does Cancer Get Started? Mainstream medicine believes that most cancer originates because of mysterious processes taking place in our genes. Environmental theories have fallen on hard...
Anti-PSA Vaccines Investigated CSF Vaccines Colony stimulating factors are hormone-like substances that accelerate the production of white blood cells. GM-CSF (granulocyte-macrophage...
Are DC Vaccines Established Medicine?Dendritic cells were actually discovered in the 19th century, but the name “dendritic cells” (DCs) was not attached to them until 1973 (by Ralph M. Steinman...
The Most Exciting Development in Oncology Signatures of Mutational Processes In Human Cancer “There is at bottom only one genuinely scientific treatment for all diseases, and that is to stimulate...
From Mitochondria to Fermentation: Cancer’s Energy Shift A human being takes in carbohydrates, which turns into glucose, or blood sugar. According to a committee of British scientists, there are...
Cancer and Exercise A study in the Journal of the American Medical Association (JAMA) showed that “among older, long-term survivors of colorectal, breast, and prostate cancer, a diet and exercise...
Role of Galectin-3 and Modified Citrus PectinGalectin-3 is a proteinGalectin-3 is a protein whose production is encoded by one particular gene (called LGALS3). It is one of 14 lectins that have...
A New Form of Electrical AblationNanoKnife seems to be significantly less destructive of normal tissue than any other method. The “NanoKnife” (despite the name) is not an instrument made of...
Photodynamic Therapy (PDT) Photodynamic therapy (PDT) is a form of cancer treatment that uses light to destroy cancer cells that have first been pre-sensitized with a drug called a...
A Bright Past and Future The use of light to treat diseases, including presumably external cancer, is very old. According to an article on the development of the field: “Phototherapy (light...
Energy MedicineIonizing forms of energy medicine consist of particles, X rays, or gamma rays in which atomic nuclei give up energy through the emission of ionizing particles. These treatments are...
Mayo Clinic scientists have devised an ingenious new way of attacking cancer cellsThey first administer a modified form of the common measles virus to invade and destroy cancer cells. The virus...
Riga Virus Therapy Available in Latvia A form of viral therapy that is available to today’s patients is Rigvir®, short for “Riga virus.” (Riga is the capital of Latvia, where this treatment was...
Metronomic chemotherapy is being used in the U.S. with some preliminary success in difficult-to-treat cancers. Nick Chen, MD, Ph.D., an oncologist who serves as medical director of the Seattle...
Laser Ablation Since 1996, Alex Rolle, MD, Chief of Thoracic and Vascular Surgery in Coswig/Dresden, Germany has been performing aggressive laser ablations of lung metastases. He has removed an...
Treatments Cancer of many kinds can spread to the bones from elsewhere in the body. In fact, bone metastases are by far the most common cause of cancer within the bones of the skeleton. Generally...
Complexity of Trial Design It is rarely shown that radiation actually extends life (i.e., median overall survival) through straightforward comparisons that are preplanned within randomized...
How does one judge the relative merits of cancer treatments? What are the standards by which a treatment is declared effective or ineffective? The American Cancer Society has an answer to this...
Large Dose Radiation Intraoperative radiation therapy (IORT) involves using a large dose of radiation delivered in surgery. Most radiation treatments have to travel through normal tissue to reach...
Common Side Effects Nausea and vomiting are among the most common side effects of cancer treatments, such as radiation and chemotherapy. Chemotherapy-induced nausea and vomiting is abbreviated as...
Israeli Clinics Introduction Israel is a small country that has many accomplishments in science and medicine. In the field of CAM, Israelis have made contributions. These include Traumeel®,...
A Visit to the IAT Clinic In March 2011, I visited the Immune Augmentative Therapy (IAT) Centre in Freeport, Bahamas. I first visited this clinic in 1980 and have been back periodically since...
Around the Los Angeles Area In March, 2005, I completed a two-week, 2,000 mile automobile trip through the state of California. I began this journey on March 2 in Long Beach, where I gave the...
CAM and Cancer in Greater Phoenix The astonishing red rocks of Sedona symbolize the deep connections of this area to holistic thinking and complementary medicine in general. We took a very...
CAM in CA The CAM situation in northern California is favorable. In other words, the chances of finding a CAM practitioner to provide intelligent help with cancer are good in this region....
Everything’s Bigger in Texas We focus our investigations in Texas on the Greater Houston area. Houston is America’s fourth largest city, and its metropolitan area encompasses 5.6 million people....
CAM in Houston Houston is America's fourth largest city, and its metropolitan area encompasses more than 5.7 million people. It is home to the largest medical complex on earth, the Texas Medical...
CAM in Italy: Personal Observations and Historical Considerations This article contains observations and historical considerations on cancer and complementary and alternative medicine (CAM) in...
Resveratrol: A Natural Phytoalexin Found in Grapes Chemical Complexity Grapes are chemically complex but have been better studied than most other plants. There are hundreds of separate...
Sulforaphane: A Potential Anticancer Agent The evidence supports sulforaphane (from broccoli) as a potential anticancer agent that could inhibit tumor development and could protect normal tissues...
Quercetin, A Natural Bioflavonoid There was an exciting presentation at the 92nd annual ASCO meeting by Nianzeng Xing, MD, PhD, then a research fellow in the Urology Department of the Mayo...
One of the Big Five Green tea is one of the “Big Five” nutraceuticals that kill cancer stem cells (per Naujokat and McKee’s excellent paper on the topic). EGCG (the main solid ingredient in green...
Physical Activity, Vitamins and Food ChoicesThe American Cancer Society recommends the following guidelines to prevent cancer, as well as heart disease, and other chronic diseases. We will...
An Introduction to Diet and Cancer “Indulge your passion for science…but let your science be human [and] have a direct reference to action and society. Be a philosopher; but amidst all your...