Melanoma Treatment Guide
This diagnosis-specific guide explains current evidence on standard treatments, including benefits, risks, side effects and key questions to ask your doctors. It is based on independent research...
Melanoma
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A Compound in Broccoli Targets Cancer Pathways
In 2024, we wrote about sulforaphane and its optimal sources in our book The Moss Method, where we placed it among the top ten primary elements of a natural anticancer diet. More recently, the...
Microbiome and Immunotherapy: The Gut Reaction
100 Trillion Reasons Your Gut Matters Why do some people respond to immune treatment for their cancers, while others get no effect? A lot of people are spending a lot of money on these “hot” new...
Immune Checkpoint Inhibitors with Nobel Laureate– Dr. James P. Allison
Dr. James P. Allison won the 2018 Nobel Prize in Medicine for his application of Immune Checkpoint Inhibitors to treat cancer. With impressive results and widespread use throughout oncology, he...
Healing Cancer with Fermented Wheat Germ Extract with Drs. Hardy and Wales
In this episode of The Moss Report Podcast, Mary Hardy, MD, and David Wales, talk with our host, Ralph W. Moss, Ph.D. about recent research on an unusual treatment: fermented wheat germ extract...
Exploring Immunotherapy with Tibor Bakács
In this episode of The Moss Report Podcast, Ralph Moss speaks with Dr. Bakács about his recent research into the problem of Immune-Related Adverse Events (IRAEs) caused by checkpoint inhibitor...
Clinic Conversations: Dr. Maharaj and Stem Cells
In this episode of The Moss Report Podcast, Ralph W. Moss, PhD speaks with Dipnarine Maharaj, MD, about his Florida-based clinic and his latest research. An expert in immunology, Dr. Maharaj has...
Taofeek Owonikoko, MD, PhD on Lung and Thyroid Cancers and Early Phase Drug Development
Dr. Taofeek Owonikoko is a Professor and Vice Chair for Faculty Development in the Department of Hematology and Medical Oncology at Emory University, Atlanta. He is also a Georgia Research...
Rose Bengal – PV-10®
ROSE BENGAL (PV-10®) One of the most unusual drugs in development for liver cancer is called “PV-10.” This is a 10% solution of a dye called “rose bengal.” Rose bengal already has a role in...
Harvard Study, Antioxidants Safe for Breast Cancer Patients?
Good News about Antioxidants A study from Harvard University has confirmed that the use of vitamin or antioxidant supplements after a diagnosis of breast cancer (BC) does not increase the risk of...
Types of Hyperthermia Equipment
The Machinery Makes a DifferenceThe effectiveness of hyperthermia depends on the machines that are available in the marketplace. Four leading manufacturers of hyperthermia equipment are Pyrexar...
Basics of Hyperthermia
What is Hyperthermia Treatment for Cancer?Clinical hyperthermia is the application of heat to the treatment of disease, in this case, cancer. The forms of electromagnetic energy that have been...
Tissue Agnostic Therapy
“Guided Missile” Drugs and Immune Checkpoint BlockadeThe dawning of the era of personalized medicine in the 21st century also holds out new prospects for patients. One can now direct...
Checkpoint Therapy Effects by Ralph W. Moss, PhD et al – Peer Reviewed Journal
Significant association between tumor mutational burden and immune-related adverse events during immune checkpoint inhibition therapies Authors: Csaba Kerepesi Tibor Bakacs Ralph W. Moss Shimon...
Interleukin-2
Does this “Wonder Drug” still hold promise? Interleukin-2 (IL-2) is a substance formed naturally in the body by what are called activated T cells, a kind of white blood cell. In a semi-synthetic...
Yervoy and Zelboraf for Melanoma
Introduction of two new drugsThe year 2011 was noteworthy for the introduction of two new drugs to treat the dangerous form of skin malignancy, melanoma. In March, the FDA approved ipilumumab...
Immune Checkpoint Blockade (ICB)
A Revolution in Cancer Therapy “Treatment of cancer has been revolutionized by immune checkpoint blockade therapies.” —Moshe Sade-Feldman, et al. Mass General Hospital, Boston “Cancer biologists...
Dichloroacetate (DCA)
DCA Therapy Relies on The Warburg EffectAn article once appeared in the magazine New Scientist, under the heading “Cheap, safe drug kills most cancers.” The drug in question was dichloroacetate...
Melanoma and Exercise
The Shape of Things to Come While mainstream oncology focuses on new pharmaceutical treatments for melanoma, there is evidence that just maintaining the patient’s underlying health can also have...
Protein from Bacteria Shrinks Tumors
Protein from Bacteria Shrinks Tumors Researchers at the University of Illinois at Chicago (UIC) have isolated a protein secreted by bacteria that effectively kills cancer cells. When tested...
T-Vec Imlygic
T-Vec (Imlygic) Imlygic (from Amgen), is an oncolytic herpes simplex virus type 1 (HSV-1) armed with the immune-boosting GM-CSF.In 2015, T-Vec (talimogene laherparepvec) a.k.a. Imlygic (from...
Viral Therapy
Renewed Interest in Viral Therapy Recently, a clinical trial on the topic of the pox virus was published in the British journal Nature. The authors stated that this was the first trial to test...
Viral Therapy – Talimogene (T-VEC) and ICB for Melanoma
FDA Approves Oncolytic Virus for MelanomaTalimogene (T-VEC)The FDA has approved the oddly named talimogene laherparepvec (Imlygic® or T-VEC®), the first FDA-approved oncolytic virus, for the...
Brain Metastases
A Major Health Problem Brain metastases were once believed to be very rare. However, because of the increased use of sophisticated diagnostic techniques such as CT and MRI scans it is now...
Does CHOP cause Metastases in NHL?
The Problem of Second Cancers Along with increased survival as a result of increasingly effective treatment in NHL, there is growing evidence that some treatment regimens themselves cause cancer....
Innovative Radiation Therapy
Ionizing Radiation Ionizing radiation, such as radium and X-rays, has been part of cancer treatment since the days of the Nobel laureate Marie Curie (1867-1934). These techniques now...
BEC5 (Curaderm®) Devil’s Apple
Unlicensed, Unapproved, and Unproven Curaderm® BEC5 is a cream containing two active ingredients: solasodine glycosides, derived from eggplants, and a less known plant from Australia, the Devil’s...
Melanoma and PV-10
Rose Bengal While most attention in melanoma has focused on two new drugs, Yervoy (ipilimumab) and Zelboraf (vemurafenib), a less-known drug has also recently demonstrated positive results. This...
Honokiol and Cancer Stem Cells
Signal Transducers and Activators Honokiol is another promising anti-CSC agent that is available to present-day cancer patients without a prescription. Honokiol is a fascinating compound that has...
Ingenol Mebutate (Picato®) – Botanicals
Euphorbia SapA common garden weed, called petty spurge (Euphorbia peplus), has been used for decades, perhaps even centuries, as a folk remedy for warts and other skin conditions. In fact, one of...
Melatonin and Metastatic Colon Cancer
IL-2 plus MelatoninIn the mid-1980s, interleukin-2 (IL-2) was much in the news as a high-dose (but also toxic) treatment for renal cell cancer and melanoma. But it was not known as an effective...
FBI and FDA Raid a Laetrile-Using Clinic
The Camelot Clinic On April 23, 2013, agents of the Food and Drug Administration (FDA), the Federal Bureau of Investigation (FBI), and the Oklahoma Medical Board raided an “alternative cancer...
Stages & Grades
Transcript I want to explain about stages of cancer and grades of cancer, and you might want to know what stage and grade your cancer is in, but I also want to talk about why that's important....
Companion Diagnostic Tests
An Excellent BusinessCompanion diagnostic testing is an excellent business, since everyone with a particular type of cancer is a candidate for the test, while only a minority who are positive for...
Prostate and PSA Testing
The ControversyIn October 2011 a national controversy broke out over the question of whether to screen healthy men for prostate cancer (PC) using the prostate-specific antigen (PSA) test. An...
Lung Cancer and Xalkori
Companion Diagnostics In August 2011, the FDA approved Pfizer’s new anticancer pill, crizotinib (Xalkori®). The approval was unusual in several respects. Approval was for a very specific...